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Tolo Biotech.

Tolo Harbour Biology discovered for the first time that CRISPR-Cas12 protein has efficient "trans-cleavage activity" and developed "Holmes/HOLMES" nucleic acid rapid detection platform technology (one-HUR Low-cost Multipurpose highly Efficient System) based on the unique advantages of the enzyme. Compared with the traditional molecular diagnostic technology, HOLMES technology based on CRISPR has the advantages of high sensitivity, high specificity, fast and convenient, and is praised as "the next generation of molecular diagnostic technology" by the American magazine Science. It has great application potential in many fields such as pathogen detection, genetic disease screening, precision medicine and so on.

Tolo Harbour Biology has a methodology patent for Cas12 nucleic acid detection (Chinese invention patent, patent number: ZL 201710573752.0;ZL 201810560284.8), and in 2019 and 2020, it reached a patent cross-licensing cooperation in the Sino-US market with Sherlock Biosciences Company, led by Professor Zhang Feng, academician of the American Academy of Sciences, on Cas12 and Cas13 diagnostic technologies. In November 2022, the two sides further signed a global CRISPR diagnostic "patent cross-licensing" cooperation agreement, completing the overall layout of Tolo Biotech's underlying methodology patents in the field of CRISPR testing.

Tolo Harbor Biology is currently actively promoting the application of HOLMES and SHERLOCK platform technologies in molecular POCT, clinical infection detection, tumor early screening and accompanying diagnosis, home detection, etc. It is also willing to join hands with in vitro diagnosis peers to promote the rapid development of CRISPR diagnosis industry.

development process


2013年

上海吐露港成立
组建创始团队

2017年

CRISPR诊断技术研究
安徽吐露港成立,产品覆盖CRISPR系列和其它分子试剂
基于CRISPR技术的HOLMES专利申请获批

2020年

完成天使轮融资
无锡吐露港成立,专注于HOLMES方法学的诊断产品开发
荣获第九届中国创新创业大赛全国总决赛优秀企业称号
与Sherlock达成专利交叉授权
荣获安徽省高层次人才团队称号

2021年

2022年

获得高新技术企业认证
无锡GMP车间落成
首单CRISPR诊断试剂出海
完成CRISPR诊断方向底层专利的全球布局
荣获上海市首届高价值专利运营大赛最高奖:投资价值奖

Qualification Honor


中华人民共和国科技部感谢信

中华人民共和国科技部感谢信

创新创业大赛江苏赛区优秀企业奖

创新创业大赛江苏赛区优秀企业奖

第九届创新创业大赛优秀企业

第九届创新创业大赛优秀企业

上海专利运营大赛投资价值奖

上海专利运营大赛投资价值奖

安徽大学校外实习基地

安徽大学校外实习基地

安徽省2020年高层次科技人才团队

安徽省2020年高层次科技人才团队

安徽省院士工作站

安徽省院士工作站

淮北师范大学创新创业教育

淮北师范大学创新创业教育

创业大赛奖杯

创业大赛奖杯

无锡生物医药行业协会理事单位

无锡生物医药行业协会理事单位

Corporate Culture


企业使命

企业使命

成为一家在健康领域持续输出创新型解决方案的平台公司

企业使命
企业愿景

企业愿景

基于CRISPR创新科技,解决全球健康威胁!

企业愿景
企业价值观

企业价值观

高效、自律、团结、担当

企业价值观